The development of portable ECG technology has found growing markets, from wearableECG sensors to ambulatory ECG recorders, encountering challenges of moderately complex totightly regulated devices. This study investigated how a typical 0.5–40 Hz bandwidth ECG isaffected by motion artifact when using analog front-end (AFE) integrated circuits such as theAD823X family. It is known that the typical amplitude resolution of current mobile health ECGdevices is 10–12 bits, and sometimes 16-bits, which is enough for monitoring but might beinsufficient to identify the small potential amplitudes useful in diagnoses. The interest now is onthe interplay of how a digital resolution choice and variable gain can cope with motion artifactsinherent in mobile health devices. With our methodology for a rapid prototyping of an ECG device,and using the AFE AD8232 and Bluetooth communication, a specific cardiac monitor ECGconfiguration was evaluated under two microcontroller systems of different resolution: a genericArduino Nano board which featured a 10-bit analog-to-digital converter (ADC) and the 24-bit ADCof Silicon Labs C8051F350 board. The ECG cardiac monitor setup, recommended by Analog Devices,featuring two gain values under these two different microcontroller systems, was explored as to itsability to solve motion artifact problems.