详细介绍工控软件组态王与单片机多机串口通讯的设计原理。分析组态王提供的直接与单片机串口通信方法的优点，给出系统基于RS-485总线传输的接口电路原理图。根据组态王提供的通讯协议和单片机多机串口通讯的原理，给出程序设计流程与思路。 Abstract: In this paper，the design principle of communication between multi-SCM and KingView by serial ports is described in detail.We analysis the advantage of method supplied by KingView,by which KingView can communicate with serial ports of SCM directly，and provide the system’s interface circuit based on the RS-485transmission line.We provide flow diagram of programming and thinking on the basis of communication protocol supplied by KingView and principle of communication among multi-SCM through serial ports.